Journal Publications
| Author | Tack B, Vita D, Mbuyamba J, Nketo J, Ntangu E, Phoba MF, Luyindula A, Nkoji G, Vuvu H, Heroes AS, Im J, Tadesse BT, Siribie M, Jeon H, Marks F, Hardy L, Allegaert K, Vlieghe E, Toelen J, Jacobs J, Lunguya O |
|---|---|
| Title | Efficacy of susceptibility-matched antibiotic treatment of nontyphoidal Salmonella bloodstream infections: a prospective observational study in hospitalized children under 5 in the Democratic of Congo. |
| Journal Name | Clin Microbiol Infect |
| Month / Year | 2026 |
| Abstract | OBJECTIVES: In sub-Saharan African children aged under 5 years, nontyphoidal Salmonella (NTS) frequently cause fatal bloodstream infections. Antimicrobial resistance and absence of antibiotic treatment efficacy data challenge effective treatment. In this prospective observational study, we provide treatment efficacy data of susceptibility-matched antibiotic regimens from the treatment of NTS bloodstream infections in children in Kisantu district hospital (Democratic Republic of Congo). METHODS: Children (>28 days to /=5 days of susceptibility-matched antibiotics, NTS persisted in control blood cultures in 15% (13/88). CONCLUSIONS: NTS bloodstream infections were often extensively drug resistant, leading to susceptibility-mismatched antibiotic treatment. When NTS were susceptible, third-generation cephalosporin, ciprofloxacin and azithromycin treatment appeared to be effective. |